Figure 2.

Cancer stem cell models, oncogene dependence, and metabolic profile. Correspondence to the normal stem and progenitor cell phenotypes of two complementary subsets of CSC identified on the basis of two models for their generation. Relationship of these subsets to oxygen and glucose supply in tissue microenvironment as well as to the activity of growth-promoting oncogene signaling. CSC, cancer stem cell; CPC, cancer progenitor cell; MRD, minimal residual disease; the width of arrows corresponds to the hypothesized level of activity.