Table 3.

Additional six middle ear ROC variables, comprising the full 21 biomarker set with odds ratio.

Domain name and number	Set number	ROC variables	No. Obs	AUC	SENS	SPEC	PPV	NPV	% Risk of rejecting Ho	ROC P value	Odds ratioa	Odds ratio P value	Accuracy
6. Middle ear (supplementary domain)	16	High threshold ear canal volume	123	0.603	0.367	0.825	0.006	0.997	0.01	<0.0001	2.74	0.0181	0.6016
	17	Low threshold peak middle ear pressure	124	0.617	0.700	0.484	0.006	0.997	0.04	0.000	2.19	0.0369	0.5887
	18	High threshold gradient middle ear pressure (90%)	124	0.580	0.370	0.891	0.013	0.997	6.74	0.0674	3.77	0.0064	0.6129
	19	High threshold stapes amplitude projected	123	0.626	0.583	0.651	0.007	0.997	0.29	0.003	2.61	0.0099	0.6179
	20	Low threshold time to offset/base length	122	0.659	0.683	0.613	0.008	0.998	0.01	0.001	3.42	0.0013	0.6475
	21	High threshold percentage base length/duration	122	0.657	0.583	0.774	0.120	0.998	0.14	0.001	4.80	0.0001	0.6803

Twenty-one biomarkers in a total of six domains for schizophrenia and schizoaffective disorder. All values reported at 95% confidence interval unless otherwise stated.

ROC, receiver operating curve; No Obs, number of observations; AUC, area under receiver operating curve (ideally >0.6); SENS, sensitivity; SPEC, specificity; pre-adjusted odds ratio (prior to division by 3), P value for odds ratio at 95% confidence interval; % RR-Ho, percentage risk ratio for null hypothesis (ideally <0.10); HPL, urinary hydroxyhemopyrroline-2-one.

^aMiddle ear domain and catecholamine domain did not require imputation.