Table 4.
Parameters and pathological cutoff values for six functional domains of biomarkers for functional psychosis.
| Domain number and name | No. ROC variables per domain | No. Obs | AUC | SENS | SPEC | PPV | NPV | % Risk of rejecting Ho | ROC P value | Odds ratio | Odds ratio P value | Accuracy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. Visual domain | 3 | 120 | 0.915 | 0.849 | 0.881 | 0.031 | 0.999 | 0.010 | <0.0001 | 41.48 | <0.0001 | 0.8667 |
| 2. Auditory domain | 3 | 119 | 0.891 | 0.868 | 0.818 | 0.021 | 0.999 | 0.01 | <0.0001 | 29.57 | <0.0001 | 0.6016 |
| 3. Catecholamine domain* | 3 | 133 | 0.859 | 0.848 | 0.746 | 0.015 | 0.999 | 0.01 | <0.0001 | 16.47 | <0.0001 | 0.9790 |
| 4. Oxidative stress (HPL/creatinine) | 1 | 133 | 0.696 | 0.697 | 0.642 | 0.009 | 0.998 | 0.01 | <0.0001 | 4.12 | <0.0001 | 0.6692 |
| 5. Biochemistry–nutrition | 5 | 126 | 0.797 | 0.548 | 0.875 | 0.019 | 0.998 | 0.39 | 0.001 | 8.5 | <0.0001 | 0.7143 |
| Combined 15-set, 5 domain | ||||||||||||
| (Not imputed), cut off ≥3 domains | 15 | 107 | 0.952 | 0.841 | 0.905 | 0.038 | 0.999 | 0.01 | <0.0001 | 50.21 | <0.0001 | 0.8707 |
| (Not imputed) cut off ≥4 domains | 107 | 0.952 | 0.659 | 0.984 | 0.158 | 0.998 | 0.01 | <0.0001 | 119.867 | <0.0001 | 0.8352 | |
| (Imputed), cut off ≥3 domains | 116 | 0.951 | 0.824 | 0.908 | 0.039 | 0.999 | 0.01 | <0.0001 | 45.89 | <0.0001 | 0.8362 | |
| (Imputed), cutoff ≥4 Domains | 116 | 0.951 | 0.647 | 0.985 | 0.160 | 0.998 | 0.01 | <0.0001 | 117.333 | <0.0001 | ||
| 6. Middle ear domain (supplementary)* | 6 | 120 | 0.738 | 0.48 | 0.520 | 0.130 | 0.997 | 0.03 | <0.0001 | 4.28 | 0.0001 | 0.6583 |
| Combined 21 set, 6 domain (imputed) with middle ear domain cutoff at 3/6 domains | 21 | 108 | 0.954 | 0.940 (0.830–0.985) | 0.833 (0.689–0.892) | 0.022 | 1.0 | 0.01 | <0.0001 | 66.93 | <0.0001 | 0.740 |
All values reported at 95% confidence interval unless otherwise stated. ROC, receiver operating curve; No Obs, number of observations; AUC, area under receiver operating curve (ideally >0.6); SENS, Sensitivity; SPEC, specificity; pre-adjusted ODDS ratio + prior to division by 3, P value for odds ratio at 95% confidence interval; % RR-Ho, percentage risk ratio for null hypothesis (ideally <0.10), HPL, urinary hydroxyhemopyrroline-2-one.
Bold font for parameters for the combined imputed and non-imputed 15 biomarker set and the combined 21 biomarker set.
*Middle ear domain and catecholamine domain did not require imputation.