Table 7.

Spearman correlations (in descending order of strength), for 15 and 21 biomarker sets and their functional domains, with separate functional measures of disability and severity.

Domains	(5 domains) 15 biomarker set (imputed)	Visual	Auditory	High catecholamine	Biochemistry–nutrition	Oxidative stress (HPL/creatinine)	Middle ear	(6 domains) 21 biomarker set (imputed)
Case versus control 525	0.770	0.730	0.650	0.598	0.458	0.339	0.340	0.775
Symptom intensity rating (SIR) for psychosis	0.697	0.624	0.583	0.467	0.404	0.327	0.377	0.636
SOFAS ROC	0.752	0.729	0.632	0.591	0.415	0.312	0.341	0.758
GAF ROC	0.770	0.745	0.618	0.562	0.415	0.315	0.328	0.742
CGI ROC	0.754	0.729	0.636	0.591	0.415	0.312	0.341	0.761
Hospital admission rate	0.830	0.766	0.608	0.583	0.403	0.421	0.300	0.748
Disability pension requirement	0.677	0.608	0.530	0.460	0.309	0.296	0.212	0.609
Model domain		Case versus control	SOFAS ROC	GAF ROC	CGI ROC	Hospital admission rate	Disability pension	Symptom intensity rating (SIR)
15 biomarker set (5 domains)		0.770	0.752	0.770	0.754	0.830	0.677	0.697
Visual domain		0.650	0.632	0.618	0.636	0.608	0.530	0.624
Auditory domain		0.650	0.632	0.618	0.636	0.608	0.530	0.583
High catecholamines		0.598	0.591	0.562	0.591	0.583	0.460	0.4677
Biochemistry–nutrition domain		0.458	0.415	0.415	0.415	0.403	0.309	0.404
Middle ear domain		0.340	0.341	0.328	0.341	0.300	0.212	0.377
Oxidative stress (HPL/creatinine)		0.339	0.312	0.315	0.312	0.421	0.296	0.327
21 biomarker set (6 domains)		0.775	0.758	0.742	0.761	0.748	0.609	0.636

All rho values are at 95% level of confidence. For rho ≥0.350, P ≤ 0.0001. SOFAS, Social and Occupational Functioning Assessment Scale; GAF, Global Assessment of Function Scale; CGI, Clinical Global Index (of Severity). Hospital admission rate as determined by number of admissions divided by duration of illness and disability pension receipt, as indices of cost burden.