Fig. 1.
a (i) A schematic illustration of the development of the NO-releasing polymer and transmission electron microscopy image of the particles, size and morphology of the NO-releasing polymers as determined by (ii) dynamic light scattering and (iii) scanning electron microscopy at ×3035. b NO release from different concentrations of NO-releasing polymers (NO-RPs). Measurements were recorded using NO measuring electrode over a period of 20 min. c NO release pharmacokinetics from the NO-releasing polymers (NO-RPs). Measurements were recorded using NO measuring electrode over a period of 8 h. d Effect of NO-releasing polymer (NO-RP) on pre-contracted pulmonary artery from control mice and mice with pulmonary arterial hypertension. Data represents mean ± SEM for n = 3 from three animals. Statistical significance was determined by two-way ANOVA followed by a Bonferroni post hoc test (*p < 0.05)