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. 2015 Jun 6;90:1225–1237. doi: 10.1007/s00204-015-1541-6

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Amount of 0594 (open circle), 0595 (filled circle), 0596 (filled triangle), 0599 (times symbol), 0600 (filled square), 0618 (hyphen symbol), amoxicillin (open triangle) and antipyrine (open diamond symbol) in the basolateral compartment in the in vitro BeWo model with increasing time using initial concentrations of 50 μM (25 nmol) in the apical compartment. Data are presented as mean ± SD (n = 3)