Table 2.
Univariable analyses of coronary stenosis severity, plaque characteristics, and FFRCT for prediction of lesion-specific ischaemia (FFR ≤0.80; N = 484 vessels).
| Overall |
Stenosis >50% (N = 239) | Stenosis ≤50% (N = 245) | ||||
|---|---|---|---|---|---|---|
| RR (95% CI) | P-value | RR (95% CI) | P-value | RR (95% CI) | P-value | |
| Stenosis >50% | 5.0 (3.0–8.3) | <0.001 | – | – | – | – |
| NCP ≥185 mm3 | 3.7 (2.4–5.6) | <0.001 | 2.2 (1.4–3.4) | 0.001 | 3.5 (1.3–9.2) | 0.013 |
| LD-NCP ≥30 mm3 | 4.6 (2.9–7.4) | <0.001 | 2.6 (1.7–4.1) | <0.001 | 5.7 (2.1–15.6) | 0.001 |
| CP ≥9 mm3 | 1.4 (1.0–2.0) | 0.070 | 1.0 (0.7–1.4) | 0.956 | 2.2 (0.8–6.0) | 0.117 |
| Total plaque volume ≥195 mm3 | 3.4 (2.3–5.2) | <0.001 | 2.0 (1.3–3.0) | 0.001 | 4.0 (1.5–10.7) | 0.006 |
| APV ≥50% | 1.8 (1.3–2.6) | 0.001 | 1.2 (0.9–1.8) | 0.207 | 1.8 (0.7–5.1) | 0.245 |
| Remodelling index >1.1 | 3.1 (1.4–6.6) | 0.004 | 1.7 (0.8–3.9) | 0.181 | 2.2 (0.6–7.7) | 0.224 |
| Plaque length ≥30 mm | 2.7 (1.8–4.0) | <0.001 | 1.6 (1.1–2.4) | 0.016 | 3.5 (1.3–9.7) | 0.014 |
| Spotty calcification | 1.3 (0.9–2.0) | 0.211 | 1.2 (0.8–1.7) | 0.427 | 2.1 (0.7–6.5) | 0.182 |
| FFRCT ≤0.80 | 13.6 (8.4–21.9) | <0.001 | 8.3 (4.5–15.1) | <0.001 | 17.7 (7.5–42.0) | <0.001 |
FFRCT, fractional flow reserve derived from coronary computed tomography angiography; FFR, fractional flow reserve; RR, relative risk; CI, confidence interval; NCP, non-calcified plaque; LD-NCP, low-density non-calcified plaque; CP, calcified plaque; APV, aggregate plaque volume.