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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Hum Pathol. 2016 Jan 7;51:96–102. doi: 10.1016/j.humpath.2015.12.017

Table 2.

Immunohistochemical staining performed in 4 cases to confirm the diagnosis of metastatic renal cell carcinoma (RCC).

Pt Diagnosis Positive markers Negative markers
3 Chromophobe RCC CK7, PAX8, CD10 (cytoplasmic), RCC (rare cells) ER, calretinin, inhibin, vimentin
4 Clear cell RCC EMA CK7, CK20
5a RCC, unclassified PAX8, vimentin, P504S, p53, CK20 (focal) CK7, WT-1, PIN dual (HMWK and p63), cytokeratin 5/6, CD10, ER
8 Clear cell RCC Vimentin, LMWK HMWK

Abbreviations: CK7 indicates cytokeratin 7; ER, estrogen receptor; EMA, epithelial membrane antigen; CK20, cytokeratin 20; P504S, alpha-methylacyl CoA racemase; HMWK, high-molecular-weight keratin; LMWK, low-molecular-weight keratin.

a

In patient 5, immunohistochemical staining was performed on both primary kidney tumor (positive for pancytokeratin AE1/AE3, E-cadherin, vimentin, CK20, CD10, CD117, P504S, and carbonic anhydrase. The tumor cells were negative for CK7, thrombomodulin, actin, HMB-45, cytokeratin 5/6, WT-1, P63, and Melan-A), as well as abdominal wall masses (as shown in the table). The primary and metastatic tumors (including the ovarian tumor) showed similar morphology, and this case was diagnosed as RCC, unclassified.