Table 1. Characteristics of 228 colon cancer patients and association of gene mutations with clinicopathological parameters.
| Characteristics | Number (%) |
KRAS |
BRAF |
PI3KCA |
NRAS |
||||
|---|---|---|---|---|---|---|---|---|---|
| Mutations (%) | P | Mutations (%) | P | Mutations (%) | P | Mutations (%) | P | ||
| Sex | |||||||||
| Male | 137 (60.1) | 49 (36.0) | 0.489 | 8 (5.8) | 0.434 | 18 (13.5) | 0.849 | 0 (0) | 0.157 |
| Female | 91 (39.9) | 37 (40.7) | 8 (8.8) | 11 (12.6) | 2 (2.2) | ||||
| Age | |||||||||
| ≤60 | 111 (48.7) | 34 (30.9) | 0.041 | 4 (3.6) | 0.049 | 13 (12.1) | 0.694 | 1 (0.9) | 0.96 |
| >60 | 117 (51.3) | 52 (44.4) | 12 (10.3) | 16 (14.2) | 1 (0.9) | ||||
| Mean | 60 ± 12 | ||||||||
| Range | 23-84 | ||||||||
| Tumor family history | |||||||||
| Yes | 23 (10.2) | 9 (40.9) | 0.82 | 0 (0) | 0.382 | 6 (26.1) | 0.09 | 0 (0) | 1.0 |
| No | 203 (89.0) | 77 (37.9) | 16 (7.9) | 22 (11.3) | 2 (1.0) | ||||
| Missing | 2 (0.8) | ||||||||
| Tumor location* | |||||||||
| Right | 107 (46.9) | 43 (40.2) | 0.584 | 7 (6.5) | 0.792 | 18 (17.1) | 0.097 | 1 (0.9) | 1.0 |
| Left | 121 (53.1) | 43 (35.8) | 9 (7.4) | 11 (9.6) | 1 (0.8) | ||||
| Tumor differentiation | |||||||||
| Well /Moderate | 191 (84.1) | 69 (36.3) | 0.356 | 13 (6.8) | 0.724 | 21 (11.5) | 0.104 | 2 (1.1) | 1.0 |
| Poor | 36 (15.5) | 16 (44.4) | 3 (8.3) | 8 (22.2) | 0 (0) | ||||
| Missing data | 1 (0.4) | ||||||||
| Tumor stage↑ | |||||||||
| II | 124 (54.4) | 48 (38.7) | 0.779 | 8 (6.5) | 0.715 | 14 (11.8) | 0.5 | 2 (1.7) | 0.5 |
| III | 104 (45.6) | 38 (36.9) | 8 (7.7) | 15 (14.9) | 0 (0) | ||||
| Depth of invasion↑ | |||||||||
| T2 | 7 (3.1) | 3 (42.9) | 1.0 | 0 (0) | 1.0 | 0 (9.7) | 0.122 | 0 (0.0) | 1.0 |
| T3 | 207 (91.2) | 78 (37.9) | 15 (7.2) | 25 (12.6) | 2 (1.0) | ||||
| T4 | 13 (5.3) | 5 (38.5) | 1 (7.7) | 4 (30.8 | 0 (0.0) | ||||
| Missing data | 1 (0.4) | ||||||||
| Nodal stage↑ | |||||||||
| N0 | 124 (54.4) | 49 (39.5) | 0.62 | 8 (6.5) | 0.94 | 14 (11.8) | 0.768 | 2 (1.7) | 1.0 |
| N1 | 58 (25.5) | 19 (32.8) | 5 (8.6) | 8 (14.5) | 0 (0.0) | ||||
| N2 | 45 (19.7) | 18 (40.9) | 3 (6.7) | 7 (15.6) | 0 (0.0) | ||||
| Missing data | 1 (0.4) | ||||||||
| Relapse | |||||||||
| Yes | 35 (15.3) | 14 (41.2) | 0.699 | 3 (8.6) | 0.725 | 4 (11.4) | 1.0 | 0 (0.0) | 1.0 |
| No | 170 (74.6) | 64 (37.6) | 12 (7.1) | 22 (13.6) | 2 (1.2) | ||||
| Missing data | 23 (10.1) | ||||||||
Tumor location*: Right is defined as right colon and transverse colon; left is defined as left colon and sigmoid colon.
↑: Seventh edition of the AJCC/UICC TNM staging systems.