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. 2016 Apr 14;6:24343. doi: 10.1038/srep24343

Figure 4. Sequence signature encoding mESC-specific H3K27ac confers mESC-specific gene expression.

Figure 4

(A) Differentiation of the H3K27ac around TSS in adult liver cells from mESC. The vertical and horizontal axes represent H3K27ac peak heights in adult liver cells and mESC, respectively. Common and cell-type specific H3K27ac peaks among mESC and adult liver cells are identified as illustrated. (B,C) mESC-specific H3K27ac peak sites encode high levels of mESC H3K27ac signatures and low levels of liver H3K27ac signature in the DNA sequences compared to liver-specific H3K27ac peaks. Liver-specific H3K27ac peak sites associate with high levels of liver-H3K27ac signatures and low levels of mESC-H3K27ac signatures in the DNA. The vertical axes are levels of H3K27ac signatures encoded in DNA of mESC (B) and liver (C), respectively. The boxplots show the distribution of H3K27ac signatures in DNA at common, mESC-specific, and liver-specific H3K27ac peak sites, respectively. (D) Log2 fold changes of RNA levels in mESC from mouse liver cells are measured in genes associated with high H3K27ac signatures in their DNA sequences around TSS. Common refers to genes associated with the probability of H3K27ac greater than 0.5 in both mESC and liver cells. mESC specific and liver specific refer to the genes associated with the probability of H3K27ac greater than 0.5 only in the mESC and liver cells, respectively, but less than 0.1 in the other cell-type.