Figure 4. Ces1^−/− mice are susceptible to MCD diet-induced liver injury.

(A–F) Ces1^+/+ mice and Ces1^−/− mice were fed an MCD diet for 4 weeks. Hepatic triglycerides (TG) and total cholesterol (TC) (A), body fat composition (B), plasma ALT level (C), as well as hepatic mRNA levels of Tnfα (D), Il1β (E), and Il6 (F) were determined. *p < 0.05, **p < 0.01. Unpaired Student t-test was used for statistical analysis.