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. 2016 Apr 14;6:24090. doi: 10.1038/srep24090

Figure 6. Reduced IL-2 production and T-cell proliferation in PBLs isolated from PI-treated patients.

Figure 6

(A,B), Lower IL-2 production (A) and decreased proliferation of PBLs (B) in PI-treated patients compared to RTI-treated and cART naive patients, respectively. PBLs were isolated from healthy, naïve and HIV-1 infected individuals under PI and RTI treatment. Five million PBLs were either left untreated or treated with rNef (100 ng/ml), anti-CD3-mAb (5 μg/ml), anti-CD28-mAb (5 μg/ml), anti-CD3-mAb + rNef, anti-CD8-mAb + rNef, and anti-CD3-mAb + anti-CD28-mAb for 24 h. IL-2 production (A) and cell proliferation (B) was measured using ELISA and MTT cell proliferation assay respectively. Means ± s.d. (n = 5).