Figure 5. Siderophores coordinately modulated the virulence-associated interactive metabolome, as the complete deletion of all four siderophores restored the perturbations in the interactive metabolome to the levels observed in the interactive metabolomes with non-UPEC and human urine.

(a) Score plot resulting from the PLS-DA analysis of the interactive metabolomes between the human urine that had been cultured with the selected strains and the pre-culture pooled human urine. (b). Heatmap visualizing the relative levels of the interactive metabolomes between the human urine that had been cultured with the selected strains and the pre-culture pooled human urine.