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Effect of 5‐HT (1 mg·kg−1 i.v., n = 6) on MVL in wild‐type (WT) and EP2 or EP4 receptor‐deficient mice (A and B) trachea and (C and D) bronchi and IPA. EP2 receptor‐deficient mice were bred on a C57BL/6 background, and EP4 receptor‐deficient mice were bred on a mixed background of 129/Ola X C57BL/6. Data expressed as mean ± SEM of the concentration of Evans blue dye (ng·mg−1 of tissue). *P < 0.05 indicates a significant increase from vehicle control.
