Table 2.
Contribution matrix for any mood episode relapse (the complete contribution matrix is shown on pp. 84–85 of the Appendix in Miura et al. [4])
| Number of comparisons | PLB vs LIT | PLB vs VPA | PLB vs LTG | PLB vs IMP | PLB vs FLX | PLB LIT+IMP | PLB vs ARP | PLB vs OLZ | PLC vs QTP | PLB RisLAI | PLB vs PAL | LIT vs VPA | LIT vs CBZ | LIT vs LTG | LIT vs IMP | LIT vs FLX | LIT vs LIT+IMP | LIT vs LIT+VPA | LIT vs LIT+OXC | LIT vs OLZ | LIT vs QTP | VPA vs LIT+VPA | VPA vs VPA+ARP | LTG vs VPA+LTG | LTG vs ARP+LTG | IMP vs LIT+IMP | OLZ vs RisLAl | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any mood eplaode | ||||||||||||||||||||||||||||
| PLB vs LIT | 10 | 27.2 | 5.3 | 13.7 | 2.3 | 0.2 | 0.0 | 4.9 | 5.7 | 2.1 | 0.0 | 3.1 | 0.0 | 13.7 | 1.8 | 0.7 | 2.2 | 0.0 | 6.9 | 5.7 | 2.2 | 0.0 | 0.0 | 0.5 | 2.1 | |||
| PLB vs VPA | 1 | 14.2 | 13.0 | 7.1 | 1.2 | 0.1 | 0.0 | 2.5 | 3.0 | 1.1 | 0.0 | 17.0 | 0.0 | 7.1 | 0.9 | 0.4 | 12.2 | 0.0 | 3.6 | 3.0 | 12.2 | 0.0 | 0.0 | 0.3 | 1.1 | |||
| PLB vs LTG | 4 | 9.9 | 1.9 | 56.5 | 0.8 | 0.1 | 0.0 | 1.8 | 2.0 | 0.7 | 0.0 | 1.1 | 0.0 | 17.2 | 0.6 | 0.3 | 0.8 | 0.0 | 2.5 | 2.0 | 0.8 | 0.0 | 0.0 | 0.2 | 0.7 | |||
| PLB vs IMP | 2 | 14.8 | 2.9 | 7.4 | 8.1 | 0.5 | 0.0 | 2.6 | 3.1 | 1.1 | 0.0 | 1.7 | 0.0 | 7.4 | 23.9 | 7.9 | 1.2 | 0.0 | 3.7 | 3.1 | 1.2 | 0.0 | 0.0 | 8.4 | 1.1 | |||
| PLB vs LIT+IMP | 1 | 14.3 | 2.8 | 7.1 | 4.3 | 1.0 | 0.0 | 2.5 | 3.0 | 1.1 | 0.0 | 1.6 | 0.0 | 7.1 | 10.3 | 20.5 | 1.2 | 0.0 | 3.6 | 3.0 | 1.2 | 0.0 | 0.0 | 14.6 | 1.1 | |||
| PLB vs ARP | 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
| PLB vs. OLZ | 2 | 11.5 | 2.2 | 5.8 | 1.0 | 0.1 | 0.0 | 22.5 | 2.4 | 9.5 | 0.0 | 1.3 | 0.0 | 5.8 | 0.8 | 0.3 | 0.9 | 0.0 | 23.0 | 2.4 | 0.9 | 0.0 | 0.0 | 0.2 | 9.5 | |||
| PLB vs. QTP | 2 | 14.4 | 2.8 | 7.2 | 1.2 | 0.1 | 0.0 | 2.6 | 23.6 | 1.1 | 0.0 | 1.6 | 0.0 | 7.2 | 0.9 | 0.4 | 1.2 | 0.0 | 3.7 | 29.4 | 1.2 | 0.0 | 0.0 | 0.3 | 1.1 | |||
| PLB vs RisLAI | 2 | 4.6 | 0.9 | 2.3 | 0.4 | 0.0 | 0.0 | 9.0 | 1.0 | 49.4 | 0.0 | 0.5 | 0.0 | 2.3 | 0.3 | 0.1 | 0.4 | 0.0 | 9.2 | 1.0 | 0.4 | 0.0 | 0.0 | 0.1 | 18.2 | |||
| PLB vs PAL | 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |||
| Manio eplaode | ||||||||||||||||||||||||||||
| PLB vs LIT | 7 | 39.4 | 11.6 | 9.5 | 0.8 | 0.4 | 0.0 | 0.6 | 5.9 | 0.2 | 0.0 | 9.4 | 0.0 | 9.5 | 0.7 | 0.5 | 2.2 | 0.0 | 0.8 | 5.9 | 2.2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | ||
| PLB vs VPA | 1 | 23.2 | 16.3 | 5.6 | 0.5 | 0.2 | 0.0 | 0.3 | 3.5 | 0.1 | 0.0 | 21.1 | 0.0 | 5.6 | 0.4 | 0.3 | 6.4 | 0.0 | 0.5 | 3.5 | 6.4 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | ||
| PLB vs LTG | 3 | 12.9 | 3.8 | 54.3 | 0.3 | 0.1 | 0.0 | 0.2 | 1.9 | 0.1 | 0.0 | 3.1 | 0.0 | 19.3 | 0.2 | 0.2 | 0.7 | 0.0 | 0.3 | 1.9 | 0.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | ||
| PLB vs IMP | 1 | 20.4 | 6.0 | 4.9 | 2.5 | 0.6 | 0.0 | 0.3 | 3.1 | 0.1 | 0.0 | 4.9 | 0.0 | 4.9 | 23.8 | 11.0 | 1.2 | 0.0 | 0 4 | 3.1 | 1.2 | 0.0 | 0.0 | 0.0 | 11.6 | 0.1 | ||
| PLB vs LIT+IMP | 1 | 21.3 | 6.0 | 4.9 | 1.4 | 1.1 | 0.0 | 0.3 | 3.0 | 0.1 | 0.0 | 4.8 | 0.0 | 4.9 | 11.3 | 23.3 | 1.1 | 0.0 | 0.4 | 3.0 | 1.1 | 0.0 | 0.0 | 0.0 | 12.7 | 0.1 | ||
| PLB vs ARP | 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 99.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| PLB vs OLZ | 2 | 1.2 | 0.4 | 0.3 | 0.0 | 0.0 | 0.0 | 54.7 | 0.2 | 20.1 | 0.0 | 0.3 | 0.0 | 0.3 | 0.0 | 0.0 | 0.1 | 0.0 | 2.1 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 20.1 | ||
| PLB vs QTP | 2 | 22.2 | 6.6 | 5.4 | 0.4 | 0.2 | 0.0 | 0.3 | 15.0 | 0.1 | 0.0 | 5.3 | 0.0 | 5.4 | 0.4 | 0.3 | 1.3 | 0.0 | 0.4 | 35.3 | 1.3 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | ||
| PLB vs RisLAI | 2 | 0.4 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | 19.4 | 0.1 | 58.5 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.8 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 20.2 | ||
| PLB vs PAL | 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | ||
| Dapreesive eplaode | ||||||||||||||||||||||||||||
| PLB vs LIT | 8 | 46.5 | 2.3 | 8.5 | 0.8 | 2.2 | 0.4 | 0.0 | 4.3 | 6.7 | 0.5 | 0.0 | 1.1 | 0.0 | 8.5 | 0.6 | 2.2 | 0.5 | 1.2 | 0.0 | 4.9 | 6.7 | 1.2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.5 |
| PLB vs VPA | 1 | 21.2 | 9.1 | 3.9 | 0.4 | 1.0 | 0.2 | 0.0 | 2.0 | 3.0 | 0.2 | 0.0 | 15.5 | 0.0 | 3.9 | 0.3 | 1.0 | 0.2 | 16.3 | 0.0 | 2.2 | 3.0 | 16.3 | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 |
| PLB vsLTG | 3 | 20.8 | 1.1 | 34.3 | 0.3 | 1.0 | 0.2 | 0.0 | 1.9 | 3.0 | 0.2 | 0.0 | 0.5 | 0.0 | 2.8.6 | 0.3 | 1.0 | 0.2 | 0.5 | 0.0 | 2..2 | 3.0 | 0.5 | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 |
| PLB vs IMP | 1 | 22.0 | 1.1 | 4.0 | 7.3 | 1.1 | 1.4 | 0.0 | 2.1 | 3.2 | 0.3 | 0.0 | 0.5 | 0.0 | 4.0 | 23.8 | 1.1 | 9.9 | 0.6 | 0.0 | 2.3 | 3.2 | 0.6 | 0.0 | 0.0 | 0.0 | 11.3 | 0.3 |
| PLB vs FLX | 2 | 17.0 | 0.9 | 3.1 | 0.3 | 39.6 | 0.1 | 0.0 | 1.6 | 2.4 | 0.2 | 0.0 | 0.4 | 0.0 | 3.1 | 0.2 | 25.6 | 0.2 | 0.4 | 0.0 | 1.8 | 2.4 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.2 |
| PLB vs LIT+IMP | 1 | 22.5 | 1.1 | 4.1 | 3.1 | 1.1 | 3.2 | 0.0 | 2.1 | 3.2 | 0.3 | 0.0 | 0.6 | 0.0 | 4.1 | 9.1 | 1.1 | 25.3 | 0.6 | 0.0 | 2.4 | 3.2 | 0.6 | 0.0 | 0.0 | 0.0 | 12.1 | 0.3 |
| PLB vs ARP | 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| PLB vs OLZ | 2 | 9.8 | 0.5 | 1.8 | 0.2 | 0.5 | 0.1 | 0.0 | 53.1 | 1.4 | 6.6 | 0.0 | 0.2 | 0.0 | 1.8 | 0.1 | 0.5 | 0.1 | 0.3 | 0.0 | 14.2 | 1.4 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 6.6 |
| PLB vs QTP | 2 | 12.9 | 0.7 | 2.4 | 0.6 | 0.6 | 0.1 | 0.0 | 1.2 | 57.7 | 0.1 | 0.0 | 0.3 | 0.0 | 2.4 | 0.2 | 0.6 | 0.1 | 0.3 | 0.0 | 1.4 | 18.2 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 |
| PLB vsRisLAI | 2 | 2.8 | 0.1 | 0.5 | 0.0 | 0.1 | 0.0 | 0 0 | 15.1 | 0.4 | 56.3 | 0.0 | 0.1 | 0.0 | 0.5 | 0.0 | 0.1 | 0.0 | 0.1 | 0.0 | 4.0 | 0.4 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 19.2 |
| PLB vs PAL | 1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 100.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
ARP aripiprazole, CBZ carbamazepine, FLX fluoxetine, IMP imipramine, LIT lithium, LTG lamotrigine, OLZ olanzapine, OXC oxcarbazepine, PAL paliperidone, PLB placebo, QTP quetiapine, RisLAI risperidone long-acting injection, VPA valproate