Table 2.

Adverse events: weeks 0 through 24

System	Number	Description
Musculoskeletal	31	Arthritis/arthralgia (15), back pain (4), unspecific pain (3) osteopenia/osteoporosis (3), morning stiffness (1), tendovaginosis stenosans (1), plantar fascia pain (1), worsening fibromyalgia (1), tendinitis calcarea (1)
Infection	25	Upper airway infection (18), herpes labialis (2), fungi infection (2), fever (3)
Gastrointestinal	13	Vomiting (4), diarrhea (3), flatulence (1), diabetes mellitus (1), abdominal cramps (1), esophageal reflux (1), aphthous ulcers (1), lip blisters (no herpes proven, 1)
Neuro-psychological	14	Patient falling (4), restless legs (1), neuropathy (1), reduced leg strength (1), fatigue (1), anxiety (1), dysesthesia (1), depression (1), hyperventilation (1), involuntary movements (1), dizziness (1)
Other	7	Leg edema (2), polyp on vocal cord (2, same patient), hypokalemia (1), suspected claudicatio (1), vitamin D deficiency (1),
Dermatological	6	Exanthema (2), hematoma (2), hair loss (1), red eye (1)