Table 1.
Enriched biological processes based on upregulated proteins
| Description | Genes involved | p value |
|---|---|---|
| Metabolism (anaerobic) | ||
| Glycolysis | GPI, LDHA|TPI1, PGK1, ENO2, ALDOA, HK2, PFKP | 0.0000 |
| Gluconeogenesis | GPI, TPI1, ENO2 | 0.0101 |
| Fructose 1,6-bisphosphate metabolic process | ALDOA, PFKP | 0.0123 |
| Glycogen biosynthetic process | GYS1, GBE1 | 0.0285 |
| Oxidation reduction | LDHA, LOX, P4HA1, P4HA2, FTH1, CYP51A1 PLOD2, PLOD1, ERO1L, LOXL2, FTL |
0.0245 |
| Protein folding | LRPAP1, PFDN4, HSPBP1, PFDN6, ERO1L | 0.0469 |
| ECM and tissue development | ||
| Collagen fibril organization | COL1A1, COL3A1, LOX, P4HA1 | 0.0010 |
| Peptidyl-proline hydroxylation to 4-hydroxy-l-proline | P4HA1, P4HA2 | 0.0046 |
| Collagen biosynthetic process | COL1A1, COL3A1 | 0.0123 |
| Epidermis development | COL1A1, COL3A1, CRABP2, COL7A1, TXNIP, PLOD1 | 0.0181 |
| Cell proliferation | CDV3, LRPAP1, NUMBL, CD81 ZAK, FTH1, APOA1, CD276 |
0.0474 |
| Cell adhesion mediated by integrin | ITGA5, ICAM1 | 0.0255 |
| Response to stimulus | ||
| Response to inorganic substance | COL1A1, FNTA, BSG, TPM1, TXNIP, ACO1, NDRG1 | 0.0128 |
| Cellular response to growth factor stimulus | COL1A1, EMD | 0.0333 |
| Response to abiotic stimulus | IKBIP, COL1A1, COL3A1, FECH ZAK, SLC2A1, TXNIP, ERO1L |
0.0333 |
| Nucleus | ||
| Nuclear envelope organization | LMNA, EMD | 0.0285 |
| Nucleocytoplasmic transport | LSG1, LMNA, TXNIP, NUTF2, AGFG1 | 0.0285 |
ECM extracellular matrix