Table 2.
Immunohistochemical analysis of temporal changes of GFRs expression in four zones of distraction callus. An overall decrease in expression of all analyzed GFRs could be observed after 14 days of consolidation. a The virtually 100% Flt-1 staining in endothelium and trabeculae lining cells not included into average expression calculation.
| Chondral tissue | Fibrous tissue | Woven bone | Trabecular bone | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IGF-1R | TGF-βR1 | PDG-FRα | Flt-1 | IGF-1R | TGF-βR1 | PDG-FRα | Flt-1* | IGF-1R | TGF-βR1 | PDG-FRα | Flt-1 | IGF-1R | TGF-βR1 | PDG-FRα | Flt-1a | |
| 0 days | ++++ | +++ | +++ | +++ | + | +++ | +++ | + | ++++ | ++++ | ++++ | ++ | ++++ | ++++ | ++++ | +++ |
| 7 days | ++ | ++ | ++ | + | + | + | + | + | +++ | ++++ | ++++ | ++ | +++ | ++++ | ++++ | ++ |
| 14 days | + | ++ | + | + | + | + | + | + | +++ | +++ | +++ | ++ | +++ | +++ | +++ | ++ |