TABLE 2.
Demographic and Clinical Characteristics
| LTL (n = 45) | RTL (n = 19) | p-value | |
|---|---|---|---|
| Age in years | |||
| Mean (SD) | 50.3 (15.2) | 53.2 (8.6) | .429 |
| Range | 18 – 78 | 36 – 65 | |
| Male, n (%) | 21 (47) | 11 (58) | .412 |
| White, n (%) | 39 (87) | 18 (95) | .664 |
| Right hand dominant, n (%) | 38 (84) | 17 (90) | .713 |
| Education, years | |||
| Mean (SD) | 14.7 (2.5) | 14.2 (2.0) | .450 |
| Range | 7 – 20 | 11 – 19 | |
| Histology, n (%) | |||
| Glioblastoma | 22 (49) | 13 (68) | .914 |
| Astrocytoma | 12 (27) | 4 (21) | |
| Oligodendroglioma | 5 (11) | 2 (11) | |
| Other | 6 (13) | 0 (0) | |
| WHO tumor gradea | |||
| High grade, n (%) | 36 (80) | 14 (74) | .202 |
| Temporal Lobe Region, n (%) | |||
| Anterior | 10 (22) | 4 (21) | .603 |
| Posterior | 12 (26) | 4 (21) | |
| Medial | 16 (36) | 10 (53) | |
| Multi | 7 (16) | 1 (5) | |
| Functional Region, n (%) | |||
| Eloquent | 16 (36) | 7 (37) | .999 |
| Near-eloquent | 27 (60) | 11 (58) | |
| Non-eloquent | 2 (4) | 1 (5) | |
| Tumor Volume,b cm3 | |||
| Mean (SD) | 23.0 (26.5) | 33.4 (29.1) | .173 |
| Range | 0.4 – 142.4 | 3.3 – 115.8 | |
| Awake Craniotomy, n (%) | 29 (64) | 1 (5) | .013* |
| Extent of Resection, % removed | 94.9 (11.6) | 94.7 (9.20) | .947 |
| Postoperative FLAIR Volume,c cm3 | |||
| Mean (SD) | 14.7 (21.8) | 21.3 (20.9) | .276 |
| Range | 0.00 – 121.3 | 0.0 – 70.3 | |
| Seizure History, n (%) yes | 19 (42) | 7 (37) | .689 |
| Therapy at Follow-up, n (%) | |||
| Chemotherapy | 2 (4) | 0 (0) | .564 |
| Radiation | 11 (24) | 4 (21) | |
| Both | 2 (4) | 0 (0) | |
| Prior Biopsy, n (%) yes | 11 (24) | 1 (5) | .090 |
| NCF Testing Interval, days | |||
| Baseline to surgery, Mean (SD) | 39.2 (28.3) | 31.0 (28.5) | .295 |
| Surgery to follow-up, Mean (SD) | 34.0 (28.3) | 28.9 (28.9) | .517 |
a
High Grade = WHO Grade III or IV.
b
LTL, n = 44; RTL, n = 19. T1 hyperintense volume for enhancing tumors; T1 hypointense volume for nonenhancing lesions
c
LTL, n = 45; RTL, n = 18.
*
Significant difference, P ≤ .05.