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. 2016 Feb 2;5(4):684–692. doi: 10.1002/cam4.623

Figure 3.

Figure 3

LSD1 inhibition partially phenocopies miR‐708 overexpression, whereas overexpression of LSD1 has opposite effects. (A). The mRNA level of LSD1 was reduced by siRNA‐LSD1‐1 or siRNA‐LSD1‐2 which specifically target LSD1. **P < 0.01. (B). Inhibition of LSD1 upregulated MDA‐MB‐231 cells invasion. *P < 0.05, **P < 0.01. (C). MDA‐MB‐231 cells grew much faster as a result of LSD1 inhibition. (D). Proliferation of MDA‐MB‐231 cells was analyzed using CCK‐8 assay. **P < 0.01. (E). LSD1 expression was upregulated with the treatment of LSD1 lentivirus infection. **P < 0.01. (F). Lentivirus infection efficiency was confirmed at 72 h by using RT‐PCR. **P < 0.01. G. Cells grew much slower with the treatment of LSD1 lentivirus infection. H. CCK‐8 assay was performed to evaluate the proliferation rate of MDA‐MB‐231 cells with the treatment of LSD1 lentivirus infection. **P < 0.01. *P < 0.05.