Table 3.
Comparison of cytokine/chemokine levels between human and PDX ascites using anti‐human antibodies
| Cytokine/chemokine | Human PMP ascites, median (range) | PDX PMP ascites, median (range) | Significance |
|---|---|---|---|
| IP‐10 | 1610 (27.98–4883) | 18.52 (0.39–4945) | ns |
| IL‐6 | 915 (268–9261) | 1.02 (1.02–124) | 0.0067 |
| MCP‐1 | 838 (188–10,443) | 30.35 (2.13–5200) | ns |
| MDC | 369 (3.05–681) | 7.89 (3.05–120) | ns |
| sCD‐40L | 305 (6.2–641) | 18.69 (6.2–2265) | ns |
| GRO | 263 (191–556) | 3.77 (3.77–493) | 0.0316 |
| IL‐8 | 195 (107–938) | 3.925 (1.19–533) | 0.0341 |
| VEGF | 103 (9.14–3792) | 2515 (1175–9850) | ns |
| Eotaxin | 56.88 (27.3–582) | 18.68 (3.59–80.96) | ns |
| IL‐10 | 56.21 (1.66–337) | 1.66 (1.66–36.89) | ns |
| IL‐1rα | 22.93 (1.82–30.67) | 1.82 (1.82–1644) | ns |
| MIP‐1β | 18.63 (0.96–43.52) | 0.96 (0.96–87.7) | ns |
| TNF‐α | 9.09 (1.25–16.21) | 1.25 (1.25–19.65) | ns |
| MIP‐1α | 7.44 (2.03–30.92) | 2.03 (2.03–13.43) | ns |
| IFNα2 | 5.1 (0.44–49.58) | 0.44 (2.14–86.39) | ns |
| IFNγ | 3.02 (1.51–8.14) | 5.64 (1.51–51.15) | ns |
| Flt‐3L | 2.14 (2.14–168) | 2.14 (2.14–86.39) | ns |
ns, not significant.