Table 4.
Comparison of cytokine/chemokine levels between human and PDX ascites using anti‐human or anti‐mouse antibodies
| Cytokine/chemokine | Human PMP (human ab) ascites, median (range)a | PDX PMP (mouse ab) ascites, median (range)b | Significance |
|---|---|---|---|
| IP‐10 | 1610 (29.98–4883) | 232 (28.17–1930) | ns |
| IL‐6 | 915 (28–9261) | 142.5 (27.24–860) | 0.0173 |
| MCP‐1 | 838 (188–10,443) | 204 (26.6–1494) | ns |
| IL‐8 (KC) | 195 (107–938) | 559.5 (121–1886) | ns |
| IL8 (MIP2) | 195 (1.25–16.21) | 62.74 (0.21–77.7) | 0.0087 |
| VEGF | 103 (107–938) | 66.28 (0.4–155) | ns |
| IL‐10 | 56.21 (1.66–337) | 6.115 (1.21–75.14) | ns |
| MIP‐1β | 18.63 (0.96–43.52) | 45.53 (4.57–216) | ns |
| TNF‐α | 9.09 (9.14–3792) | 7.78 (21.7–6314) | ns |
| MIP‐1α | 7.44 (2.03–30.92) | 34.05 (10.9–119.3) | 0.0173 |
| IFNγ | 3.02 (1.51–8.14) | 0.95 (0.94–33.58) | ns |
ns, not significant.
a
Assays performed with anti‐human antibodies raised against listed antigens.
b
Assays performed with anti‐mouse antibodies raised against listed antigens.