Table 3.

Univariate and multivariate meta-regression analyses of potential source of heterogeneity.

Heterogeneity factors	Coefficient	SE	z	P	95%CI
					LL	UL
Publication year
Univariate	0.036	0.015	2.34	0.019	0.006	0.067
Multivariate	0.029	0.041	0.71	0.480	−0.051	0.109
SNP type
Univariate	0.064	0.110	0.58	0.559	−0.151	0.280
Multivariate	0.074	0.113	0.65	0.513	−0.148	0.296
Ethnicity
Univariate	−0.334	0.124	−2.69	0.007	−0.576	−0.091
Multivariate	−0.293	0.182	−1.61	0.107	−0.650	0.063
Disease
Univariate	−0.233	0.098	−2.37	0.018	−0.426	0.040
Multivariate	−0.076	0.139	−0.55	0.586	−0.347	0.196
Genotyping method
Univariate	−0.121	0.100	−1.21	0.226	−0.317	0.075
Multivariate	0.210	0.203	1.04	0.300	−0.187	0.607

SE – standard error; 95%CI – 95% confidence interval; UL – upper limit; LL – lower limit; SNP – single-nucleotide polymorphisms.