Figure 7.

Effect of acute in vivo administration of LY379268 on the 15 mM KCl‐evoked [³H]‐d‐Asp overflow from synaptosomes isolated from the spinal cord of control (non‐immunized) and EAE mice. Control (untreated) mice and EAE (grey bar) mice at the acute stage of disease (21 d.p.i.) were acutely injected i.p. (doses as indicated) and then killed within 3 h. The spinal cord was rapidly removed, and synaptosomes were prepared to monitor the 15 mM KCl‐evoked [³H]‐d‐Asp overflow in in vitro experiments. Results are expressed as 15 mM KCl‐induced overflow; data are means of nine experiments run in triplicate. *P < 0.05 versus the 15 mM KCl‐evoked tritium overflow from untreated mice; ^# P < 0.05 versus the 15 mM KCl‐evoked tritium overflow from untreated EAE mice.