Figure 5.
Probing the effect of trimetazidine (TMZ) administration in vitro on cardiac fatty acid oxidation using lower concentrations of palmitoylcarnitine (1–15 μmol·L−1). Mitochondrial fatty acid oxidation was assessed in the presence of ADP and FCCP. No effect of acute TMZ administration (10 μmol·L−1) with any of the tested palmitoylcarnitine (Pc) concentrations was observed. M, malate, n = 6 patients. Stepwise increments of Pc concentration resulted in a significant increase in oxygen consumption within the same experimental group (P < 0.05), *P < 0.05 versus no TMZ and TMZ in vitro. ww, wet tissue wt.