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Protection by geniposide (GE; 100 μM for 24 h) was mediated by GLP‐1 receptor. (A) The mRNA levels of GLP‐1 receptor in the hypertrophic hearts (n = 5). (B) The mRNA levels of GLP‐1R in H9c2 cells (n = 5). (C) The cross‐sectional areas of H9c2 myocytes (n = 5). (D) Ex9‐39 (10 μM for 24 h) blocks protection by geniposide in H9c2 cells (n = 6). (E) Ex9‐39 blunts protection by geniposide in neonatal rat cardiomyocytes (n = 6). (F) Effects of Ex9‐39 on AMPKα and ACC (n = 6). * P < 0.05.
