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. 2016 Feb 26;173(9):1478–1490. doi: 10.1111/bph.13444

Figure 3.

Figure 3

Relaxations induced by the Kv7 activators, ML213 and BMS204352, do not involve NOS activity or endothelium‐derived hyperpolarizations through IKCa/SKCa channels in penile arteries and corpus cavernosum. Concentration‐dependent relaxations for ML213 in penile arteries (A) and corpus cavernosum strips (B), and for BMS204352 in penile arteries (C) and corpus cavernosum strips (D) from 3‐month‐old Wistar rats in the absence and presence of the NOS inhibitor, L‐NAME (100 μM), or the IKCa and SKCa channel blockers, TRAM‐34 (1 μM) and apamin (0.3 μM). Data are mean ± SEM. n = 5. Two‐way ANOVA with Bonferroni's post hoc test. *P < 0.05 from control.