Figure 4.

K_v7 channel inhibition reduces relaxations to the NO donor, SNP, and the PDE5 inhibitor, sildenafil, in penile arteries and corpus cavernosum. Concentration‐dependent relaxations for SNP (A) and sildenafil (C) in the absence and presence of linopirdine (lino, 10 μM) in penile arteries from 3 month‐old Wistar rats. Concentration‐dependent relaxations for SNP (B) and sildenafil (D) in the absence and presence of linopirdine (lino, 10 μM) in corpus cavernosum strips from 3‐month‐old Wistar rats. EC₅₀ and E_max values for SNP‐induced and sildenafil‐induced relaxations are represented for penile arteries in (E) and for corpus cavernosum strips in (F). Data are mean ± SEM. n = 6 and n = 5 for each experimental group of penile arteries and corpus cavernosum respectively. Student's unpaired t‐test. *P < 0.05 from control.