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. 2016 Feb 26;173(9):1478–1490. doi: 10.1111/bph.13444

Figure 5.

Figure 5

Relaxations to the NO donor, SNP, and the PDE5 inhibitor, sildenafil, as well as the effect of Kv7 channel inhibition are reduced in penile arteries and corpus cavernosum. Concentration‐dependent relaxations of SNP (A) and sildenafil (C) in penile arteries from 3‐month‐old Wistar and SHHF rats in the absence and presence of linopirdine (lino, 10 μM). Concentration‐dependent relaxations of SNP (B) and sildenafil (D) in corpus cavernosum strips from 3‐month‐old Wistar and SHHF rats in the absence and presence of linopirdine (lino, 10 μM). EC50 and Emax values for SNP‐induced and sildenafil‐induced relaxations are represented for penile arteries in (E) and for corpus cavernosum strips in (F). Data are mean ± SEM. n = 6 and n = 5 for each experimental group of penile arteries and corpus cavernosum respectively. One‐way ANOVA with Bonferroni's post hoc test. *P < 0.05.