Table 3.
Summary of studies examining cerebral blood flow variables in the Vannucci model. Summary of referenced studies including blood flow measurement technique, effect of ligation and hypoxia, and resuscitation in air or 100% oxygen
| Study (Technique) | Species (Age) | Anesthesia | Effect on cerebral blood flow | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| hHypoxia | During Hypoxia | Resuscitation (air) | 100% Oxygen | |||||||
| Ligated side | Unligated side | Ligated side | Unligated side | Ligated side | Unligated side | Ligated side | Unligated side | |||
| Vannucci et al. (1988) | Rat | N/A | ↔ | ↑ (Frontal Cortex) | ↓ (Global) | ↔ | N/A | N/A | ||
| iodo[14C]antipyrine | (P7) | ↑ (Cerebellum) | ↑ (Cerebellum) | |||||||
| Ek et al. (2015) | Mouse | N/A | N/A | ↓ | ↑ | ↓ (2 h) | ↓ (2 h) | N/A | ||
| iodo[14C]antipyrine | (P7) | ↔ (6 h) | ↔ (6 h) | |||||||
| Presti et al. (2006) | Mouse | N/A | N/A | ↓ | ↔ | ↔ | ↔ | ↑ | ↔ | |
| LDF | (P7/P8) | |||||||||
| Qiao et al. (2004) | Rat | Isoflurane | ↓ (Global) | ↔ | ↓ | ↔ | ↔ | ↔ | N/A | |
| MRI | (P7) | |||||||||
| Ohshima et al. (2012) | Rat | Isoflurane | ↓ (Global) | ↔ | N/A | ↑ | ↔ | N/A | ||
| LSI | (P7) | |||||||||
| Taniguchi et al. (2014) | Mouse | Isoflurane | ↓ | N/A | ↓ | ↓ | ↓ | ↓ | N/A | |
| LSI | (P9) | ↑ (vs hypoxia) | ||||||||
| Buckley et al. (2015) | Rat | N/A | ↓ | ↓ | N/A | ↑ (immediate) | ↑ (immediate) | N/A | ||
| DCS | (P10) | ↔ (2 h) | ↔ (2 h) | |||||||
| This study | Rat | Ketamine + | ↓ | ↔ | ↓ | ↓ | ↓ | ↓ | ↑ (vs air) | ↔ (vs air) |
| LSI | (P10) | Medetomidine | ↑ (vs hypoxia) | ↑ (vs hypoxia) | ||||||
LDF, laser Doppler flowmetry; MRI, magnetic resonance imaging; LSI, laser speckle imaging; DSC, diffuse correlation spectroscopy.
Blood flow changes are relative to preligation baseline values unless otherwise stated. ↑ = increased, ↓ = decreased, ↔ = no change, N/A = not applicable (not measured).