Table 1.
Logistic regression analysis of associations between the genotypes of XPG and stomach cancer susceptibility in a Chinese population
| Genotype | Cases (N = 692) | Controls (N = 771) | P a | Crude OR (95% CI) | P | Adjusted OR (95% CI)b | P b |
|---|---|---|---|---|---|---|---|
| rs2094258 C>T | |||||||
| CC | 287 (41.47) | 291 (37.74) | 0.296c | 1.00 | 1.00 | ||
| CT | 304 (43.93) | 368 (47.73) | 0.84 (0.67–1.05) | 0.119 | 0.85 (0.68–1.06) | 0.150 | |
| TT | 101 (14.60) | 112 (14.53) | 0.91 (0.67–1.25) | 0.577 | 0.92 (0.67–1.26) | 0.601 | |
| Additive | 0.93 (0.80–1.08) | 0.313 | 0.93 (0.80–1.08) | 0.347 | |||
| Dominant | 405 (58.53) | 480 (62.26) | 0.145d | 0.86 (0.69–1.06) | 0.145 | 0.86 (0.70–1.07) | 0.177 |
| Recessive | 591 (85.40) | 659 (85.47) | 0.970e | 1.01 (0.75–1.35) | 0.970 | 1.00 (0.75–1.35) | 0.980 |
| rs751402 C>T | |||||||
| CC | 286 (41.33) | 351 (45.53) | 0.227c | 1.00 | 1.00 | ||
| CT | 313 (45.23) | 331 (42.93) | 1.16 (0.93–1.45) | 0.184 | 1.17 (0.91–1.49) | 0.221 | |
| TT | 93 (13.44) | 89 (11.54) | 1.28 (0.92–1.78) | 0.140 | 1.11 (0.77–1.61) | 0.576 | |
| Additive | 1.14 (0.98–1.33) | 0.088 | 1.09 (0.92–1.29) | 0.335 | |||
| Dominant | 406 (58.67) | 420 (54.47) | 0.106d | 1.19 (0.96–1.46) | 0.106 | 1.15 (0.92–1.45) | 0.226 |
| Recessive | 599 (86.56) | 682 (88.46) | 0.273e | 1.19 (0.87–1.62) | 0.272 | 1.03 (0.73–1.46) | 0.872 |
| rs2296147 T>C | |||||||
| TT | 442 (63.87) | 475 (61.61) | 0.464c | 1.00 | 1.00 | ||
| CT | 217 (31.36) | 264 (34.24) | 0.88 (0.71–1.10) | 0.273 | 0.93 (0.73–1.19) | 0.562 | |
| CC | 33 (4.77) | 32 (4.15) | 1.11 (0.67–1.83) | 0.688 | 1.38 (0.78–2.44) | 0.268 | |
| Additive | 0.95 (0.80–1.14) | 0.586 | 1.03 (0.84–1.25) | 0.809 | |||
| Dominant | 250 (36.13) | 296 (38.39) | 0.371d | 0.91 (0.73–1.12) | 0.372 | 0.97 (0.77–1.23) | 0.823 |
| Recessive | 659 (95.23) | 739 (95.85) | 0.567e | 1.16 (0.70–1.90) | 0.566 | 1.41 (0.81–2.48) | 0.227 |
| rs873601G>A | |||||||
| GG | 172 (24.86) | 205 (26.59) | 0.087c | 1.00 | 1.00 | ||
| GA | 333 (48.12) | 396 (51.36) | 1.00 (0.78–1.29) | 0.986 | 1.08 (0.81–1.42) | 0.604 | |
| AA | 187 (27.02) | 170 (22.05) | 1.31 (0.98–1.75) | 0.067 | 1.33 (0.96–1.84) | 0.086 | |
| Additive | 1.14 (0.99–1.32) | 0.071 | 1.15 (0.98–1.36) | 0.088 | |||
| Dominant | 520 (75.14) | 566 (73.41) | 0.449d | 1.10 (0.87–1.39) | 0.450 | 1.15 (0.89–1.50) | 0.287 |
| Recessive | 505 (72.98) | 601 (77.95) | 0.027e | 1.31 (1.03–1.66) | 0.027 | 1.27 (0.97–1.65) | 0.084 |
| Combined effect of risk genotypes | |||||||
| 0 | 145 (20.95) | 200 (25.94) | 0.023c | 1.00 | 1.00 | ||
| 1 | 367 (53.03) | 408 (52.92) | 1.24 (0.96–1.60) | 0.099 | 1.20 (0.90–1.60) | 0.211 | |
| 2 | 180 (26.01) | 163 (21.14) | 1.52 (1.13–2.06) | 0.006 | 1.44 (1.03–2.01) | 0.035 | |
| 0 | 145 (20.95) | 200 (25.94) | 1.00 | 1.00 | |||
| 1–2 | 547 (79.05) | 571 (74.06) | 0.025 | 1.32 (1.04–1.69) | 0.025 | 1.27 (0.97–1.66) | 0.088 |
a
Chi‐squared test for genotype distributions between stomach cancer cases and controls.
b
Adjusted for age, gender, BMI, smoking and drinking status.
c
Additive models.
d
Dominant models.
e
Recessive models.
OR, odds ratio; CI, confidence interval.
The results were in bold, if the 95% CI excluded 1 or P<0.05.