Table 2.
Variables | rs873601 (cases/controls) | Adjusted ORa (95% CI) | P a | Risk genotypes (cases/controls) | Adjusted ORa (95% CI) | P a | ||
---|---|---|---|---|---|---|---|---|
GG/GA | AA | 0 | 1–2 | |||||
Median age, year | ||||||||
≤59 | 249/275 | 84/85 | 1.05 (0.72–1.53) | 0.812 | 64/92 | 269/268 | 1.44 (0.97–2.14) | 0.070 |
>59 | 256/326 | 103/85 | 1.54 (1.05–2.25) | 0.028 | 81/108 | 278/303 | 1.13 (0.77–1.65) | 0.538 |
Gender | ||||||||
Females | 146/170 | 54/55 | 1.06 (0.65–1.75) | 0.810 | 45/55 | 155/170 | 1.04 (0.62–1.74) | 0.891 |
Males | 359/431 | 133/115 | 1.37 (1.00–1.89) | 0.052 | 100/145 | 392/401 | 1.40 (1.01–1.93) | 0.043 |
Smoking status | ||||||||
Never | 310/275 | 117/86 | 1.14 (0.80–1.64) | 0.463 | 98/82 | 329/279 | 0.94 (0.65–1.36) | 0.737 |
Ever | 195/326 | 70/84 | 1.43 (0.95–2.15) | 0.085 | 47/118 | 218/292 | 1.83 (1.20–2.80) | 0.005 |
Pack‐year | ||||||||
0 | 310/275 | 117/86 | 1.14 (0.80–1.64) | 0.463 | 98/82 | 329/279 | 0.94 (0.65–1.36) | 0.737 |
≤27 | 100/201 | 33/49 | 1.29 (0.73–2.29) | 0.385 | 24/75 | 109/175 | 1.83 (1.02–3.33) | 0.045 |
>27 | 95/125 | 37/35 | 1.52 (0.82–2.84) | 0.185 | 23/43 | 109/117 | 1.87 (0.97–3.61) | 0.062 |
Drinking status | ||||||||
Never | 394/420 | 145/119 | 1.26 (0.92–1.73) | 0.144 | 108/140 | 431/399 | 1.41 (1.02–1.94) | 0.036 |
Ever | 111/181 | 42/51 | 1.27 (0.75–2.13) | 0.377 | 37/60 | 116/172 | 0.97 (0.57–1.64) | 0.896 |
BMI | ||||||||
<18.5 | 38/4 | 15/1 | 1.76 (0.17–18.58) | 0.640 | 13/1 | 40/4 | 0.87 (0.08–9.37) | 0.907 |
18.5–24.0 | 301/195 | 122/49 | 1.62 (1.11–2.38) | 0.013 | 87/61 | 336/183 | 1.30 (0.89–1.90) | 0.170 |
>24.0 | 166/402 | 50/120 | 1.00 (0.68–1.47) | 0.993 | 45/138 | 171/384 | 1.33 (0.90–1.97) | 0.148 |
Tumour sites | ||||||||
Cardia | 148/601 | 51/170 | 1.17 (0.79–1.74) | 0.433 | 43/200 | 156/571 | 1.16 (0.78–1.73) | 0.472 |
Non‐cardia | 357/601 | 136/170 | 1.36 (1.01–1.82) | 0.041 | 102/200 | 391/571 | 1.33 (0.98–1.81) | 0.064 |
Adjusted for age, gender, BMI, smoking and drinking status.
OR: odds ratio; CI: confidence interval; BMI: body mass index.
The results were in bold, if the 95% CI excluded 1 or P<0.05.