Figure 2.

The genetic organization of copper‐responding gene clusters in Methylococcus capsulatus. Genomic regions containing clusters of genes and operons with copper responding transcription are depicted. ORFs are colored based on predicted functional categories as green (c‐type cytochromes), red (biosynthesis of cofactors), orange (transport), transcription regulation (purple), methane oxidation (blue), chaperones (dark blue), and hypothetical proteins (white). Number of heme‐binding motifs are shown above the individual ORFs, and putative sigma54 promoters are indicated. The sequence upstream of MCA0424 with putative binding sites for FUR, integration host factor (IHF), and RNA polymerase σ ⁵⁴ factor is shown in detail.