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. 2015 Nov 17;99(5):735–747. doi: 10.1189/jlb.3A0315-093RRR

Figure 4. P-selectin is present in the intraocular tumor and along the ciliary body in IFN-γ KO and WT tumor-bearing eyes.

Figure 4.

Mice were injected with Ad5E1 tumor cells into the AC, and the eyes were removed for histology 14 d later. P-selectin–positive staining is brown (3,3′-diaminobenzidine), and the cellular counterstain is blue (Hematoxylin QS). Intraocular P-selectin staining is not seen in the secondary control alone (A) but is seen in the AC tumor of WT (B) and IFN-γ KO (C) mice. The ciliary body of the secondary section alone shows background melanin staining (D). Positive P-selectin staining (red arrows) borders the ciliary body in WT (E) and IFN-γ KO (F) mice. There is no appreciable staining in the retina above the background expressed in specimens treated with the secondary Ab alone (G) or both WT (H) and IFN-γ KO (I) mice. Images are at ×40 magnification and are representative of 3 eye sections each from 3 to 6 mice per group.