Table 2.

Baseline and on-treatment response factors associated with hepatitis B surface antigen reduction

Factors	F	P
Baseline factors
Age (>45 years)	9.681	0.003
Gender	0.439	0.511
HBV genotype	0.923	0.346
HBV DNA (≥7.0 log10 IU/ml)	3.774	0.058
ALT (≥2 × ULN)	0.730	0.397
HBeAg-positive	0.575	0.452
HBsAg (≥3.0 log10 IU/ml)	2.384	0.130
On-treatment response factors
HBeAg seroconversion at 6 months	11.018	0.002
HBsAg reduction (≥0.5 log10 IU/ml) at 6 months	6.906	0.012

HBV: Hepatitis B virus; ALT: Alanine aminotransferase; ULN: Upper normal limit; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen.