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. 2016 Apr 20;129(8):967–975. doi: 10.4103/0366-6999.179794

Figure 4.

Figure 4

Inhibition of STAT3 neutralized the therapeutic and anti-inflammatory effect of IL-10 on ALF. (a) Western blotting analysis of liver tissues for pSTAT3 at 7th day after injecting D-Gal. (b) Concentrations of ALT and AST in blood serum at 3rd day after D-Gal injection. (c) Serum levels of TNF-α, IFN-γ, and IL-6 of each group at 3rd day after D-Gal injection. *P < 0.05 versus ALF + IL-10 group. STAT3: Signal transducer and activator of transcription 3; pSTAT3: Phosphorylated signal transducer and activator of transcription 3; D-Gal: D-galactosamine; ALF: Acute liver failure; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TNF-α: Tumor necrosis factor α; IFN-γ: Interferon-γ; IL: Interleukin.