Table 5.
Comparison of HT and CT in the eradication of Helicobacter pylori
| First author, year | Region | Center (n) | Duration | Cases (n) | Cure rate of ITT (%) | Cure rate of PP (%) | Compliance (%) | Overall rate of adverse effects (%) | Discontinued medication due to adverse effects (n) |
|---|---|---|---|---|---|---|---|---|---|
| Molina-Infante, 2013[10] | Spain/Italy | 4 | 14d HT | 171 | 90.0 | 92.0 | 98.8 | 47.0 | 2.4 |
| 14d CT | 172 | 91.8 | 96.2 | 95.2 | 56.0 | 6.0 | |||
| Zullo, 2013[18] | Italy | 3 | 14d HT | 90 | 80.0 | 85.7 | 93.3 | 24.4 | 6.7 |
| 5d CT | 90 | 85.6 | 91.7 | 93.3 | 30.0 | 6.7 | |||
| De Francesco, 2014[19] | Italy | 1 | 14d HT | 110 | 82.7 | 95.8* | NR | 22.7 | 6.4 |
| 5d CT | 110 | 78.2 | 85.1 | NR | 24.5 | 5.5 | |||
| 14d CT | 110 | 86.4 | 95.0 | NR | 26.4 | 7.3 | |||
| Cuadrado-Lavín, 2015[13] | Spain | 3 | 10d HT | 120 | 90.8 | 93.9 | 98.3 | 67.5 | 1.7 |
| 10d CT | 120 | 89.9 | 90.3 | 96.7 | 65.8 | 5.0 | |||
| Heo, 2015[14] | Korea | 6 | 10d HT | 241 | 78.8 | 89.6 | 95.0 | NR | 0† |
| 10d CT | 238 | 78.6 | 89.9 | 90.1 | NR | 3.2 | |||
| Pooled-data analysis | HT | 732 | 84.1 (615/731) | 91.4 (602/659) | 96.5 (577/598) | 42.4 (207/488) | 2.7 (19/703) | ||
| CT | 840 | 84.6 (708/837) | 91.5 (686/750) | 93.3 (559/599) | 42.8 (255/596) | 5.3 (43/818) |
*P<0.05: 14d HT versus 5d CT; †P<0.05: 10d HT versus 10d CT. CT: Concomitant therapy; HT: Hybrid therapy; ITT: Intention-to-treat; NR: Not reported; PP: Per-protocol; ST: Sequential therapy; TT: Triple therapy; d: Days.