Table 1.
Clinical characteristics of IBC and IBCA patients
| Parameters | IBC subgroup | IBCA subgroup | P |
|---|---|---|---|
| Sex (n) | |||
| Male | 4 | 13 | 0.01* |
| Female | 37 | 21 | |
| Mean age (years) | 45.4 ± 17.0 | 57.5 ± 10.9 | 0.02† |
| Presenting symptoms (n) | |||
| Abdominal pain/discomfort | 28 | 24 | 0.16* |
| Asymptomatic | 14 | 6 | |
| Abdominal mass | 2 | 1 | |
| Weight loss | 9 | 5 | |
| Jaundice/occasional cholangitis | 3 | 9 | |
| Back pain | 1 | 0 | |
| Melena/hematemesis | 2 | 0 | |
| Duration of symptoms (months) | 69.2 ± 88.2 | 57.3 ± 85.6 | 0.12‡ |
| Serum CA19-9 (U/ml) | 193.8 ± 428.7 | 1103 ± 4249.8 | 0.32‡ |
| Serum CEA (ng/ml) | 1.59 ± 0.86 | 18.4 ± 76.3 | 0.36‡ |
| ALT (U/L) | 29.8 ± 29.7 | 88.3 ± 114.2 | 0.01‡ |
| TBIL (μmol/L) | 18.9 ± 15.1 | 28.9 ± 88.4 | 0.04‡ |
| Tumor location (n) | 0.24* | ||
| Left laterality | 21 | 22 | |
| Right laterality | 14 | 6 | |
| Bilateral laterality | 5 | 6 | |
| Tumor size (cm) | 11.7 ± 5.7 | 7.1 ± 4.3 | 0.00† |
| Radiological findings (n) | |||
| Wall (thickened, irregular/thin) | 33/8 | 30/4 | 0.36* |
| Tumor capsule (complete/discontinuity) | 36/5 | 26/8 | 0.19* |
| Internal septa (yes/no) | 29/12 | 26/8 | 0.58* |
| Mural nodules (yes/no) | 26/15 | 29/5 | 0.03* |
| Septal enhancement (yes/no) | 32/9 | 30/4 | 0.25* |
| Calcifications (yes/no) | 6/35 | 7/27 | 0.50* |
| Communication with biliary duct (yes/no) | 8/33 | 7/27 | 0.91* |
| Mesenchymal stroma (yes/no) | 24/17 | 18/16 | 0.63* |
*Chi-square test; †Student’s t-test; ‡Wilcoxon rank sum test. IBC: Intrahepatic biliary cystadenoma; IBCA: Intrahepatic biliary cystadenocarcinoma; CEA: Carcinoembryonic antigen; ALT: Alanine aminotransferase; TBIL: Total bilirubin; CA: Carbohydrate antigen.