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. 2015 May 5;128(9):1238–1244. doi: 10.4103/0366-6999.156141

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Copyright: © 2015 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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MicroRNA (miRNA) biogenesis is a multistep process: Transcription, Cropping and Dicing (cytoplasm). Primary microRNA (Pri-miRNA): Polyadenilated RNA transcripts; pre-miRNA: The hairpin-loop RNAs; mature miRNA: One strand of the duplex remains on the argonaute proteins (AGO). Pre-miRNA is recognized by the Exportin/Ran-GTP complex transporter and exported to the cytoplasm. Dicer and AGO mediate the process of pre-miRNA. Drosha: The nuclear enzyme of the RNase III family; AGO: Argonaute proteins.