Table 1.
Expression of miRNAs and potential relative signaling pathway in malignant glioma
| miRNA | Level of expression | Reference | Signaling pathway |
|---|---|---|---|
| MiR21 | Up-regulation | 13,18 | TGF, STAT3 |
| MiR199b | Up-regulation | 21 | Notch1 |
| MiR203 | Up-regulation | 22 | Cell cycle |
| MiR221/222 | Up-regulation | 18,25 | AKT, apoptosis |
| MiR26b | Up-regulation | 28 | AKT |
| MiR182 | Up-regulation | 42 | / |
| MiR10b | Up-regulation | 27 | AKT |
| MiR181 | Down-regulation | 17,18,29 | Calcium signaling pathway |
| MiR128 | Down-regulation | 19,20 | P53, RTK signaling, mTOR |
| MiR153 | Down-regulation | 47 | / |
| MiR34a | Down-regulation | 23 | P53 pathway, Notch |
| MiR451 | Down-regulation | 50 | AKT, AMPK |
| MiR146b | Down-regulation | 31 | / |
| MiR17 | Down-regulation | 50 | / |
| MiR184 | Down-regulation | 53 | / |
| MiR326 | Down-regulation | 61 | Notch |
| MiR7 | Down-regulation | 24 | AKT, EGFR |
TFG: Transforming growth factor; EGFR: Epidermal growth-factor receptor; miRNA: Micro RNA.