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. 2016 Apr 4;11:1395–1412. doi: 10.2147/IJN.S96862

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© 2016 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Anti-tumor study in H22 tumor-bearing mice.

Notes: (A) Tumor growth in H22 tumor-bearing mice of DM-NCTD and DM-NCTD liposome groups after H22 cells were injected at day 0 (2 mg/kg per day, administered on days 1–9, and killed on day 10; n=10); (B) H22 tumor-bearing mice weight change of DM-NCTD and DM-NCTD liposome groups after H22 cells were injected at day 0 (2 mg/kg per day, administered on days 1–9, and killed on day 10; n=10); (C) tumors of H22 tumor-bearing mice stained with TUNEL after in vivo antineoplastic activity study (bar 20 μm). **P<0.01, *P<0.05 vs DM-NCTD group; ^##P<0.01, ^#P<0.05 vs DM-NCTD/PEG liposome group.

Abbreviations: DM, diacid metabolite; NCTD, norcantharidin; FA, folic acid; PEG, polyethylene glycol; PBS, phosphate-buffered saline; TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling.

Anti-tumor study in H22 tumor-bearing mice.

Notes: (A) Tumor growth in H22 tumor-bearing mice of DM-NCTD and DM-NCTD liposome groups after H22 cells were injected at day 0 (2 mg/kg per day, administered on days 1–9, and killed on day 10; n=10); (B) H22 tumor-bearing mice weight change of DM-NCTD and DM-NCTD liposome groups after H22 cells were injected at day 0 (2 mg/kg per day, administered on days 1–9, and killed on day 10; n=10); (C) tumors of H22 tumor-bearing mice stained with TUNEL after in vivo antineoplastic activity study (bar 20 μm). **P<0.01, *P<0.05 vs DM-NCTD group; ^##P<0.01, ^#P<0.05 vs DM-NCTD/PEG liposome group.

Abbreviations: DM, diacid metabolite; NCTD, norcantharidin; FA, folic acid; PEG, polyethylene glycol; PBS, phosphate-buffered saline; TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling.