Table 2.

IC₅₀ of various groups against H22 cells for 24 hours and 48 hours in vitro (n=3)

Group	IC50 on H22 cell lines (μg/mL)
	24 hours	48 hours
DM-NCTD	39.6±1.20	30.0±1.73
DM-NCTD/PEG liposomes	164.0±1.57**	92.5±1.31**
DM-NCTD/FA-PEG liposomes	95.3±1.52**,##	50.1±1.04**,##

Notes:

^**P<0.01 vs DM-NCTD group;

^##P<0.01 vs DM-NCTD/PEG liposome group. Data presented as mean ± standard deviation.

Abbreviations: IC₅₀, half-maximal inhibitory concentration; DM, diacid metabolite; NCTD, norcantharidin; PEG, polyethylene glycol; FA, folic acid.