Table 4.

Tissue and tumor-targeting parameters of DM-NCTD and DM-NCTD liposomes in H22 tumor-bearing mice after intravenous administration while tumor volume reached approximately 300 mm³ (2 mg/kg, n=6)

Tissue/tumor sample	Re		Te (%)			RTe		Ce
	DM-NCTD/PEG liposomes	DM-NCTD/FA-PEG liposomes	DM-NCTD	DM-NCTD/PEG liposomes	DM-NCTD/FA-PEG liposomes	DM-NCTD/PEG liposomes	DM-NCTD/FA-PEG liposomes	DM-NCTD/PEG liposomes	DM-NCTD/FA-PEG liposomes
Heart	1.08	1.3	2.85	1.49	1.79	0.52	0.63	1.3	1.93
Liver	1.86	1.64	36.03	32.46	28.83	0.9	0.8	2.17	2.47
Spleen	4.41	2.73	18	38.55	23.88	2.14	1.33	2.17	1.42
Lung	2.47	2.14	6.47	7.76	6.74	1.2	1.04	1.54	3
Kidney	0.46	0.94	31.22	6.93	14.32	0.22	0.46	0.37	0.87
Tumor	4.86	9.25	5.43	12.81	24.44	2.36	4.50	4.78	9.24

Abbreviations: DM, diacid metabolite; NCTD, norcantharidin; R_e, relative intake rate; T_e, tumor-targeting efficacy; R_Te, relative targeting efficiency; C_e, peak concentration ratio; PEG, polyethylene glycol; FA, folic acid.