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. 2016 Apr 4;9:1927–1943. doi: 10.2147/OTT.S93720

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© 2016 Sacco and Worden. This work is published and licensed by Dove Medical Press Limited

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ErbB family of receptors and their associated signaling pathways and downstream effects.

Abbreviations: Akt, v-akt murine thymoma viral oncogene homologue; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; Erk, extracellular signal-related kinase; Mek, mitogen-activated protein kinase kinase; PI3K, phosphatidylinositol-3-kinase; PLC-γ, phospholipase-C gamma; PKC, protein kinase C; Ras, rat sarcoma viral oncogene homologue; Raf, Raf proto-oncogene, serine/threonine kinase; STAT, signal transducers and activators of transcription; TGF-α, transforming growth factor alpha.