Fig 4. Aggressive treatment guaranteeing infection clearance using a classical regime, without relying on host immunity.

Antibiotic dose and treatment duration can be traded-off against one another, at any treatment onset (lines depict τ₁ varying between 2 days and 5 days), to achieve the same final result: infection clearance by the end of therapy. We apply Eq 19 to two infection scenarios: A) a = 0.1, very high resistance; and B) a = 0.3 lower resistance of the drug-resistant bacterial sub-population. Parameters as in Table 1.