Table 1. Patient material and clinical characteristics.
| Patient | Age/Sex/Race, Primary surgical treatment | Focus size/cm | Distance between foci/cm | ER | PR | HER2 | E-cad | Location | Histology/subtype | TNM stage | Final Stage | Grade | ALND, # pos LN | Genomic data | Adjacent normal available |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 44 / F / White | 4.0 | >4.0 | + | + | - | - | Right UOQ | Lobular/classic | T2 N3a M0 | IIIC | 1 | yes, right, 23/25 | yes | yes |
| R MRM and L total mastectomy | 1.8 | + | - | - | - | Right LOQ | Lobular/classic | T2 N3a M0 | 1 | yes | |||||
| 1.0 | + | + | - | Left UOQ | Lobular/classic | T1b N0 M0 | 1 | yes | |||||||
| 2 | 61 / F / White | 3.5 | 2.7 | + | - | - | - | Right UOQ | Lobular/pleomorphic | T2 N2a M0 | IIIC | 2 | yes, 7/18 | yes | yes |
| R mastectomy with ALND | 1.5 | + | + | - | - | Right UOQ | Lobular/classic | T2 N2a M0 | 1 | yes | |||||
| 1.0 | Right UOQ | Lobular/classic | T2 N2a M0 | 1 | no | ||||||||||
| 0.5 | Right UOQ | Lobular/classic | T2 N2a M0 | 1 | no | ||||||||||
| 3 | 66 / F / White | 5.0 | 1.4 | + | + | - | - | Right UOQ/midline | Lobular/pleomorphic | T2 N1a M0 | IIB | 2 | yes, 1/25 | yes | |
| R mastectomy with ALND | 1.4 | + | + | - | - | Right UIQ | Lobular/classic | T2 N1a M0 | 1 | yes | |||||
| 4 | 87 / F / White | 6.5 | >3.0 | + | + | - | - | Right UOQ | Lobular/alveolar | T3 N1a M0 | IIIA | 2 | yes, 1/23 | yes | yes |
| R mastectomy with ALND | 1.4 | + | + | - | - | Right LOQ | Lobular/classic | T3 N1a M0 | 1 | yes | |||||
| 5 | 66 / F / White | 2.5 | 3.5 | + | + | - | - | Right UOQ | Lobular/pleomorphic | T2 N0 M0 | IIA | 2 | no | yes | |
| R lumpectomy and SLNB | 2.2 | + | + | - | - | Right UOQ | Lobular/pleomorphic | T2 N0 M0 | 2 | yes | |||||
| 6 | 56 / F / White | 2.0 | 3.0 | + | + | - | - | Right UOQ | Lobular/classic | T1c N0 M0 | IA | 1 | no | yes | yes |
| R mastectomy and SLNB | 1.2 | + | + | - | - | Right UOQ | Lobular/classic | T1c N0 M0 | 1 | yes | |||||
| 7 | 65 / F / White | 1.2 | 11.0 | + | + | - | +* | Right UIQ | Lobular/trabecular | T1c N0 M0 | IA | 1 | no | yes | yes |
| bilateral mastectomy and SLNB | 0.8 | + | + | - | - | Right UOQ | Lobular/classic | T1c N0 M0 | 1 | yes | |||||
| 8 | 68 / F / White | 2.0 | 13.0 | + | - | - | - | Left LIQ | Lobular/classic | T1c N1a M0 | IIA | 1 | yes, 2/10 | yes | |
| L mastectomy with ALND | 1.5 | + | + | - | - | Left UOQ | Lobular/classic | T1c N1a M0 | 1 | yes | |||||
| 9 | 67 / F / White | 3.2 | 2.5 | + | + | - | - | Left UIQ | Lobular/pleomorphic | T2 N3a M0 | IIIC | 2 | yes, 11/33 | yes | |
| L mastectomy with ALND | 1.0 | + | + | - | - | Left UIQ | Lobular/classic | T2 N0 M0 | 1 | yes | |||||
| 10 | 60 / F / White | 6.0 | 3.0 | + | + | - | - | Right LIQ | Lobular/pleomorphic | T3 N3a M0 | IIIC | 2 | yes, 14/24 | yes | yes |
| R mastectomy with ALND | 0.7 | + | + | - | - | Right LOQ | Lobular/pleomorphic | T3 N3a M0 | 2 | yes | |||||
| 0.3 | Right UOQ | Lobular/pleomorphic | T3 N3a M0 | 2 | no | ||||||||||
| 11 | 73 / F / White | 4.5 | 1.5 | + | + | - | - | UI and UOQ | Lobular/pleomorphic | T2 N1a M0 | IIB | 2 | yes, 2/24 | yes | yes |
| R mastectomy with ALND | 0.6 | + | + | - | - | Right central | Lobular/pleomorphic | T2 N1a M0 | 2 | yes |
Abbreviations: MRM, modified radical mastectomy; UOQ, Upper outer quadrant; UIQ, upper inner quadrant; LOQ, left outer quadrant; ALND, Axillary lymph node dissection; SLNB, Sentinel lymph node biopsy.
* Weakly positive. This tumor was dominant classic lobular, with some mixed trabecular pattern.