| ISG20- interferon stimulated exonuclease gene 20kDa (Q96AZ6) |
74.6 2.0x10-3 |
Exhibit antiviral activity against RNA viruses (nucleus, cytoplasm) |
Up-regulated in cervical cancer [70] |
| MRPS22—mitochondrial ribosomal protein S22 (P82650) |
63.8 1.4x10-4
|
Protein synthesis (mitochondria) |
Marker for epithelial breast cancer cells [71] |
| ACOX3- acyl-coenzyme A oxidase 3 (O15254) |
54.2 5.0x10-4
|
Fatty acid beta-oxidation (peroxisome) |
A SNP is highly associated with prediction of outcome of CLL [72], and possibly with prostate cancer [73] |
| UBE3A- ubiquitin protein ligase E3A (Q05086) |
45.5 1.1x10-3
|
Targeting proteins for degradation (cytoplasm) |
Over-expressed in breast cancer [74]. Catalyzes the ubiquitination of p53 [75] |
| RPl13a- 60S ribosomal protein L13a (P40429) |
41.0 1.4x10-3
|
Associated with ribosomes but not with the canonical ribosome function, having extra-ribosomal functions (cytoplasm) |
Involved in cancer stem cells [76] |
| SLC25A1- solute carrier family 25, member 1 (P53007) |
17.5 6.4x10-4
|
Citrate transporter (mitochondria) |
High expression in several tumor types [77] |
| GCD- glutaryl-Coenzyme A dehydrogenase (Q92947) |
8.7 2.3x10-3
|
Involved in the degradation of L-lysine, L-hydroxylysine, and L-tryptophan (mitochondria) |
Overexpressed in colon cancer [78] |
| HP1BP3- heterochromatin protein 1, binding protein 3 (Q5SSJ5) |
6.5 1.5x10-3
|
Maintains heterochromatin integrity during G1/S progression (nucleus) |
Indications for role in hypoxia-induced oncogenesis [79] |
| CABIN1- calcineurin binding protein1 (Q9Y6J0) |
4.2 2.3x10-3
|
Inhibits calcineurin-mediated signal transduction (nucleus) |
Down-regulated in nasopharyngeal carcinoma sensitizes them to genotoxic drugs. In B-cell lymphoma, regulates the oncogene CBL6 [80] |
| PPP2R1A- Protein Phosphatase 2, Regulatory Subunit A, Alpha (P30153) |
3.4 1.5x10-3
|
Regulation of cell adhesion; second-messenger-mediated signaling; mitotic nuclear envelope reassembly and more (cytoplasm) |
Marker for risk of breast cancer [81] |
| Aprt- adenine phosphoribosyl- transferase (P07741) |
3.4 3.1x10-3
|
Involved in purine salvage pathway resulting in the formation of AMP (cytoplasm) |
Sensitizes cells to treatment with E. coli purine nucleoside phosphorylase [82] |
| CTSS- cathepsin S (P25774) |
3.0 2.5x10-3
|
Protease in MHC-II- mediated antigen presentation (lysosome) |
Overexpressed in glioblastoma [83] Prognosis and predictor marker of chemotherapy benefit in adjuvant colorectal cancer [84] |
| PSMC5- proteasome (prosome, macropain) 26S subunit, ATPase 5 (also known as S8; p45; SUG1; TBP10; TRIP1) (P62195) |
2.7 2.9x10-3
|
ATP-dependent degradation of ubiquitinated proteins (cytoplasm) |
Its gene amplified during progression of cutaneous malignant melanoma [85] |
| Nop56- Nuclear protein 56 (O00567) |
2.5 3.0x10-3
|
Involved in the 60S ribosomal subunit biogenesis (nucleus) |
Necessary for Myc-induced cell transformation [86] |
| Enpp4- ectonucleotide pyrop-hosphatase/phosphodiesterase 4 (Q9Y6X5) |
-51.8 4.4x10-3
|
Hydrolyze phosphodiester bonds, act as a procoagulant (cell membrane) |
High expression in the in vivo metastatic osteosarcoma cells [87] |
| DHRS4- dehydrogenase /reductase (SDR family) member 4 (Q9BTZ2) |
84.5 3.0x10-3
|
Reduces all-trans-retinal and 9-cis retinal (peroxisome) |
No direct association reported |
| TBL2- transducin (beta)-like 2 (Q9Y4P3) |
10.3 2.9x10-3
|
Associate with triglyceride metabolism (ER) |
No direct association reported |
| RPE- ribulose-5-phosphate-3-epimerase (Q96AT9) |
8.0 1.3x10-3
|
Pentose phosphate pathway (cytoplasm) |
No direct association reported |
| Snx18- sorting nexin 18 (Q96RF0) |
3.6 8.9x10-4
|
Endocytosis and vesicle trafficking during interphase and at the end of mitosis (cell membrane) |
No direct association reported |
