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. 2016 Apr 15;27(8):1358–1366. doi: 10.1091/mbc.E15-10-0738

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© 2016 Chen et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Overexpression of PRMT5 suppresses H₂O₂-induced activation of ASK1. (A) HUVECs were infected with either Ad-PRMT5 or Ad-GFP for 48 h and then treated with 300 μm H₂O₂ for 24 h. Cell viability assay (*p < 0.05 compared with control group). (B) Cell lysates obtained from A were subjected to Western blot. Phosphorylation of ASK1 at Ser-83 and cleaved-caspase-3 was determined. Methylation of ASK1 was determined by immunoprecipitation with antibody to ASK1.