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Outcome in patients with Klatskin tumor. We tried neoadjuvant chemotherapy (NAC) for two or three courses, then continued down-staging of chemotherapy in 7 out of 40 patients. Finally, five patients with above stent and 13 patients with across stent were successfully treated with R0 surgery. This regimen (GS) provides patients with gemcitabine 1000 mg/m2 on days 1 and 8 plus S-1 60, or 80 mg/day on days 1 through 14 of a 21-day cycle.
