Figure 4.

Intraperirhinal DPFE reduces relapse index in long-access meth rats subjected to the novel cue relapse test. (a) Self-administration behavior from Experiment 3. *p<0.05 compared with the first long-access session (infusions). (b) Time course of lever pressing behavior over the 1-h novel cue relapse test indicating more pronounced effects of treatment early in the session (15-min, eg before habituation to the novel cue). (c) Intraperirhinal DPFE reduces relapse index on the novel cue relapse test. *p<0.05 compared with vehicle. ++p<0.01 compared with a hypothetical mean of 0.50.